› 5emv

X-ray diffraction
2Å resolution

Crystal structure of the palmitoylated human TEAD2 transcription factor

Released:
DOI: 10.2210/pdb5emv/pdb
PDB entry 5emv coloured by chain, front view.
PDB entry 5emv coloured by chain, side view.
PDB entry 5emv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
Noland CL, Gierke S, Schnier PD, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ, Cunningham CN
Structure 24 179-186 (2016)
PMID: 26724994

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 236 amino acids
Theoretical weight: 26.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15562 (Residues: 218-446; Coverage: 51%)
Gene names: TEAD2, TEF4
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand P1L 2 x P1L

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Unit cell:
a: 79.83Å b: 61.25Å c: 112.672Å
α: 90° β: 101.89° γ: 90°
R-values:
R R work R free
0.203 0.202 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

47 review citations

The Hippo Signaling Pathway in Development and Disease.
Zheng et al. (2019)
46 more

10 mentions without citation

Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors.
Holden et al. (2018)
9 more