› 5en1

X-ray diffraction
2.58Å resolution

Crystal structure of hnRNPA2B1 in complex with RNA

Released:
DOI: 10.2210/pdb5en1/pdb
PDB entry 5en1 coloured by chain, front view.
PDB entry 5en1 coloured by chain, side view.
PDB entry 5en1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
Wu BX, Su SC, Patil DP, Liu HH, Gan JH, Jaffrey SR, Ma JB
Nat Commun (2018)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149683 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoproteins A2/B1 Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 21.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22626 (Residues: 12-195; Coverage: 52%)
Gene names: HNRNPA2B1, HNRPA2B1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
RNA (5'-R(*AP*GP*GP*AP*CP*UP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.26 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2
Unit cell:
a: 122.623Å b: 46.38Å c: 37.516Å
α: 90° β: 96.02° γ: 90°
R-values:
R R work R free
0.194 0.192 0.236
Expression systems:
  • Escherichia coli
  • Not provided

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