› 5epj

X-ray diffraction
1.6Å resolution

Crystal Structure of chromodomain of CBX7 in complex with inhibitor UNC3866

Released:
DOI: 10.2210/pdb5epj/pdb
PDB entry 5epj coloured by chain, front view.
PDB entry 5epj coloured by chain, side view.
PDB entry 5epj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu Y, Tempel W, Walker JR, Stuckey JI, Dickson BM, James LI, Frye SV, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132083 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromobox protein homolog 7 Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95931 (Residues: 7-62; Coverage: 22%)
Gene name: CBX7
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
peptide-like inhibitor UNC3866 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 795 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand UNX 13 x UNX
2 modified residues:
Ligand ELY 1 x ELY
Ligand 5R5 1 x 5R5

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P41212
Unit cell:
a: 40.286Å b: 40.286Å c: 82.092Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.237 0.26
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links