› 5feb

X-ray diffraction
1.35Å resolution

Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain

Released:
DOI: 10.2210/pdb5feb/pdb
PDB entry 5feb coloured by chain, front view.
PDB entry 5feb coloured by chain, side view.
PDB entry 5feb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binary architecture of the Nav1.2-β2 signaling complex.
Das S, Gilchrist J, Bosmans F, Van Petegem F
Elife 5 (2016)
PMID: 26894959

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel subunit beta-2 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60939 (Residues: 30-151; Coverage: 66%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 28.7Å b: 59.42Å c: 71.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.206
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease.
Hull et al. (2018)
3 more

6 mentions without citation

Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels.
Salvage et al. (2020)
5 more