› 5ffg

X-ray diffraction
2.25Å resolution

Crystal structure of integrin alpha V beta 6 head

Released:
DOI: 10.2210/pdb5ffg/pdb
PDB entry 5ffg coloured by chain, front view.
PDB entry 5ffg coloured by chain, side view.
PDB entry 5ffg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Force interacts with macromolecular structure in activation of TGF-β.
Dong X, Zhao B, Iacob RE, Zhu J, Koksal AC, Lu C, Engen JR, Springer TA
Nature 542 55-59 (2017)
PMID: 28117447

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139209 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-V heavy chain Chain: A
Molecule details ›
Chain: A
Length: 601 amino acids
Theoretical weight: 65.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06756 (Residues: 31-429, 430-627; Coverage: 59%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-6 Chain: B
Molecule details ›
Chain: B
Length: 257 amino acids
Theoretical weight: 28.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18564 (Residues: 128-378; Coverage: 33%)
Gene name: ITGB6
Sequence domains: Integrin beta chain VWA domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
5 bound ligands:
Ligand CA 6 x CA
Ligand NAG 2 x NAG
Ligand SO4 1 x SO4
Ligand MES 1 x MES
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 215.59Å b: 77.56Å c: 59.07Å
α: 90° β: 101.46° γ: 90°
R-values:
R R work R free
0.208 0.208 0.246
Expression system: Escherichia coli

Quick links

Citations

53 review citations

Transforming growth factor-β1 in regulatory T cell biology.
Moreau et al. (2022)
52 more

4 mentions without citation

Force interacts with macromolecular structure in activation of TGF-β.
Dong et al. (2017)
3 more