› 5fn7

X-ray diffraction
2.3Å resolution

Crystal structure of human CD45 extracellular region, domains d1-d2

Released:
DOI: 10.2210/pdb5fn7/pdb
PDB entry 5fn7 coloured by chain, front view.
PDB entry 5fn7 coloured by chain, side view.
PDB entry 5fn7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Initiation of T cell signaling by CD45 segregation at 'close contacts'.
Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ
Nat Immunol 17 574-582 (2016)
PMID: 26998761

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140183 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase C Chains: A, B
Molecule details ›
Chains: A, B
Length: 186 amino acids
Theoretical weight: 21.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08575 (Residues: 225-394; Coverage: 13%)
Gene names: CD45, PTPRC
Sequence domains: Leukocyte receptor CD45

Ligands and Environments

2 bound ligands:
Ligand NAG 9 x NAG
Ligand HG 2 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P63
Unit cell:
a: 149.61Å b: 149.61Å c: 52.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.202 0.238
Expression system: Homo sapiens

Quick links

Citations

40 review citations

TCR Signaling: Mechanisms of Initiation and Propagation.
Courtney et al. (2018)
39 more

1 mention without citation

Initiation of T cell signaling by CD45 segregation at 'close contacts'.
Chang et al. (2016)