› 5fta

X-ray diffraction
2.64Å resolution

Crystal structure of the N-terminal BTB domain of human KCTD10

Released:
DOI: 10.2210/pdb5fta/pdb
PDB entry 5fta coloured by chain, front view.
PDB entry 5fta coloured by chain, side view.
PDB entry 5fta coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas DM, Sanvitale CE, Bufton JC, Sorrell FJ, Solcan N, Chalk R, Doutch J, Bullock AN
Biochem J 474 3747-3761 (2017)
PMID: 28963344

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 112 amino acids
Theoretical weight: 12.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H3F6 (Residues: 26-135; Coverage: 35%)
Gene names: KCTD10, MSTP028, ULR061
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:
Ligand HG 4 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 48.15Å b: 83.66Å c: 58.68Å
α: 90° β: 95.18° γ: 90°
R-values:
R R work R free
0.228 0.226 0.258
Expression system: Escherichia coli BL21

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Citations

8 review citations

Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics.
Asmar et al. (2020)
7 more

4 mentions without citation

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas et al. (2017)
3 more