› 5fxq

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08069 (Residues: 980-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GD5 1 x GD5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P212121
Unit cell:
a: 40.932Å b: 66.798Å c: 121.479Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
not available not available 0.275
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Standing on the shoulders of giants: a retrospective analysis of kinase drug discovery at AstraZeneca.
Kettle et al. (2016)
5 other articles

2 mentions without citation

Transformer neural network for protein-specific de novo drug generation as a machine translation problem.
Grechishnikova D. (2021)
1 more