› 5g4x

X-ray diffraction
2.17Å resolution

The crystal structure of the SHANK3 N-terminus

Released:
DOI: 10.2210/pdb5g4x/pdb
PDB entry 5g4x coloured by chain, front view.
PDB entry 5g4x coloured by chain, side view.
PDB entry 5g4x coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.
Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J
Nat Cell Biol 19 292-305 (2017)
PMID: 28263956

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191643 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and multiple ankyrin repeat domains protein 3 Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 38.63 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: Q9JLU4 (Residues: 1-348; Coverage: 20%)
Gene names: Prosap2, Shank3
Sequence domains: Ankyrin repeats (3 copies)

Ligands and Environments

1 bound ligand:
Ligand EDO 30 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P41212
Unit cell:
a: 86.76Å b: 86.76Å c: 158.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.163 0.186

Quick links

Citations

12 review citations

Every step of the way: integrins in cancer progression and metastasis.
Hamidi et al. (2018)
11 more

7 mentions without citation

Scaffold proteins as dynamic integrators of biological processes.
DiRusso et al. (2022)
6 more