› 5gzc

X-ray diffraction
1.08Å resolution

Crystal structure of Galectin-8 N-CRD with part of linker

Released:
DOI: 10.2210/pdb5gzc/pdb
PDB entry 5gzc coloured by chain, front view.
PDB entry 5gzc coloured by chain, side view.
PDB entry 5gzc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker.
Si Y, Wang Y, Gao J, Song C, Feng S, Zhou Y, Tai G, Su J
Int J Mol Sci 17 (2016)
PMID: 27973456

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-8 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00214 (Residues: 7-158; Coverage: 48%)
Gene name: LGALS8
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 40.557Å b: 49.376Å c: 76.684Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.157 0.163
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives.
Wdowiak et al. (2018)
1 more

3 mentions without citation

Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.
Su et al. (2018)
2 more