› 5i0h

X-ray diffraction
1.8Å resolution

Crystal structure of myosin X motor domain in pre-powerstroke state

Released:
DOI: 10.2210/pdb5i0h/pdb
PDB entry 5i0h coloured by chain, front view.
PDB entry 5i0h coloured by chain, side view.
PDB entry 5i0h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The myosin X motor is optimized for movement on actin bundles.
Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, Sweeney HL, Houdusse A
Nat Commun 7 12456 (2016)
PMID: 27580874

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190807 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-X Chains: A, B
Molecule details ›
Chains: A, B
Length: 741 amino acids
Theoretical weight: 85.62 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9HD67 (Residues: 1-741; Coverage: 36%)
Gene names: KIAA0799, MYO10
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand ADP 2 x ADP
Ligand MG 2 x MG
Ligand BEF 2 x BEF
Ligand EDO 18 x EDO
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P1
Unit cell:
a: 76.48Å b: 78.3Å c: 78.67Å
α: 75.69° β: 86.38° γ: 76.12°
R-values:
R R work R free
0.167 0.165 0.19
Expression system: unidentified baculovirus

Quick links

Citations

8 review citations

MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.
Weck et al. (2017)
7 more

3 mentions without citation

The myosin X motor is optimized for movement on actin bundles.
Ropars et al. (2016)
2 more