› 5i9j

X-ray diffraction
1.74Å resolution

Structure of the cholesterol and lutein-binding domain of human STARD3 at 1.74A

Released:
DOI: 10.2210/pdb5i9j/pdb
PDB entry 5i9j coloured by chain, front view.
PDB entry 5i9j coloured by chain, side view.
PDB entry 5i9j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the lutein-binding domain of human StARD3 at 1.74 Å resolution and model of a complex with lutein.
Horvath MP, George EW, Tran QT, Baumgardner K, Zharov G, Lee S, Sharifzadeh H, Shihab S, Mattinson T, Li B, Bernstein PS
Acta Crystallogr F Struct Biol Commun 72 609-18 (2016)
PMID: 27487925

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
StAR-related lipid transfer protein 3 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14849 (Residues: 216-444; Coverage: 52%)
Gene names: CAB1, MLN64, STARD3
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

3 bound ligands:
Ligand TLA 1 x TLA
Ligand SO4 1 x SO4
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: P3121
Unit cell:
a: 83.39Å b: 83.39Å c: 82.19Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.17 0.169 0.192
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

From carotenoid intake to carotenoid blood and tissue concentrations - implications for dietary intake recommendations.
Böhm et al. (2021)
3 more

7 mentions without citation

The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates.
Widjaja-Adhi et al. (2020)
6 more