› 5ikw

X-ray diffraction
2.41Å resolution

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

Released:
DOI: 10.2210/pdb5ikw/pdb
PDB entry 5ikw coloured by chain, front view.
PDB entry 5ikw coloured by chain, side view.
PDB entry 5ikw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Counago RM, Sorrell FJ, Krojer T, Savitsky P, Elkins JM, Axtman A, Drewry D, Wells C, Zhang C, Zuercher W, Willson TM, Arrowsmith CH, Edwards AM, Bountra C, Arruda P, Gileadi O, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192596 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BMP-2-inducible protein kinase Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NSY1 (Residues: 38-345; Coverage: 27%)
Gene names: BIKE, BMP2K, HRIHFB2017
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

1 bound ligand:
Ligand 6BU 1 x 6BU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 41.957Å b: 111.155Å c: 164.053Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.216
Expression system: Escherichia coli BL21(DE3)

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