› 5jzv

X-ray diffraction
2.07Å resolution

The structure of D77G hCINAP-ADP

Released:
DOI: 10.2210/pdb5jzv/pdb
PDB entry 5jzv coloured by chain, front view.
PDB entry 5jzv coloured by chain, side view.
PDB entry 5jzv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Bai D, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao X, Ji J, Zheng X
Nat Commun 7 12310 (2016)
PMID: 27477389

Function and Biology Details

Reaction catalysed: 
ATP + AMP = 2 ADP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195201 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase isoenzyme 6 Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3D8 (Residues: 1-172; Coverage: 100%)
Gene names: AD-004, AK6, CGI-137, CINAP
Sequence domains: AAA domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P61
Unit cell:
a: 101.757Å b: 101.757Å c: 58.854Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.235
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Uncovering the assembly pathway of human ribosomes and its emerging links to disease.
Bohnsack et al. (2019)
7 more

1 mention without citation

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Bai et al. (2016)