Function and Biology Details
Reaction catalysed:
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- FAD/NAD(P)-binding domain superfamily
- Glycine cleavage T-protein, C-terminal barrel domain
- Glycine cleavage T-protein/YgfZ, C-terminal
- Aminomethyltransferase, folate-binding domain
- GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
- FAD dependent oxidoreductase, central domain
- Aminomethyltransferase-like
- FAD dependent oxidoreductase
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Dimethylglycine dehydrogenase, mitochondrial (preferred)
PDBe Complex ID:
PDB-CPX-193773 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dimethylglycine dehydrogenase, mitochondrial
Molecule details ›
Chains: A, B
Length: 841 amino acids
Theoretical weight: 94.31 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii
UniProt:
Sequence domains:
Length: 841 amino acids
Theoretical weight: 94.31 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii
UniProt:
- Canonical:
Q9UI17 (Residues: 29-866; Coverage: 97%)
Sequence domains:
- FAD dependent oxidoreductase
- FAD dependent oxidoreductase central domain
- Aminomethyltransferase folate-binding domain
- Glycine cleavage T-protein C-terminal barrel domain
