5lgd

X-ray diffraction
2.07Å resolution

The CIDRa domain from MCvar1 PfEMP1 bound to CD36

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-147791 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Platelet glycoprotein 4 Chain: A
Molecule details ›
Chain: A
Length: 472 amino acids
Theoretical weight: 53.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16671 (Residues: 1-472; Coverage: 100%)
Gene names: CD36, GP3B, GP4
Sequence domains: CD36 family
PfEMP1 variant 1 of strain MC Chain: B
Molecule details ›
Chain: B
Length: 179 amino acids
Theoretical weight: 20.92 KDa
Source organism: Plasmodium falciparum
Expression system: Homo sapiens
UniProt:
  • Canonical: Q25733 (Residues: 576-754; Coverage: 6%)
Gene name: MCvar-1 PfEMP1
Sequence domains: PFEMP1 DBL domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 129.826Å b: 40.726Å c: 138.836Å
α: 90° β: 114.85° γ: 90°
R-values:
R R work R free
0.214 0.212 0.253
Expression system: Homo sapiens