› 5lji

X-ray diffraction
2.07Å resolution

Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target

Released:
DOI: 10.2210/pdb5lji/pdb
PDB entry 5lji coloured by chain, front view.
PDB entry 5lji coloured by chain, side view.
PDB entry 5lji coloured by chain, top view.
Source organism: Streptococcus pneumoniae
Primary publication:
Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.
Rodríguez-Cárdenas Á, Rojas AL, Conde-Giménez M, Velázquez-Campoy A, Hurtado-Guerrero R, Sancho J
PLoS One 11 e0161020 (2016)
PMID: 27649488

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Flavodoxin Chains: A, C
Molecule details ›
Chains: A, C
Length: 148 amino acids
Theoretical weight: 16.29 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8DPG4 (Residues: 1-147; Coverage: 100%)
Gene names: flaV, spr1175
Sequence domains: Flavodoxin
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand FMN 2 x FMN
Ligand CA 7 x CA
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: R3
Unit cell:
a: 101.676Å b: 101.676Å c: 68.285Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens.
Salillas et al. (2020)
3 other articles

2 mentions without citation

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.
Rodríguez-Cárdenas et al. (2016)
1 more