› 5mkw

X-ray diffraction
2Å resolution

Crystal structure of the human ZRANB3 HNH domain

Released:
DOI: 10.2210/pdb5mkw/pdb
PDB entry 5mkw coloured by chain, front view.
PDB entry 5mkw coloured by chain, side view.
PDB entry 5mkw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the function of ZRANB3 in replication stress response.
Sebesta M, Cooper CDO, Ariza A, Carnie CJ, Ahel D
Nat Commun 8 15847 (2017)
PMID: 28621305

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177126 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA annealing helicase and endonuclease ZRANB3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 14.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5FWF4 (Residues: 948-1067; Coverage: 11%)
Gene name: ZRANB3
Sequence domains: HNH endonuclease

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 56.841Å b: 67.552Å c: 92.161Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.236
Expression system: Escherichia coli

Quick links

Citations

13 review citations

The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Griffin et al. (2019)
12 more

4 mentions without citation

Structural insights into the function of ZRANB3 in replication stress response.
Sebesta et al. (2017)
3 more