› 5mvx

X-ray diffraction
2.17Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta-like protein 4 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 34.23 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9NR61 (Residues: 27-325; Coverage: 45%)
Gene names: DLL4, UNQ1895/PRO4341
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 127.896Å b: 49.753Å c: 70.031Å
α: 90° β: 109.15° γ: 90°
R-values:
R R work R free
0.185 0.182 0.229
Expression system: Drosophila melanogaster

Quick links

Citations

7 review citations

Notch signaling pathway: architecture, disease, and therapeutics.
Zhou et al. (2022)
6 more

4 mentions without citation

Biophysics of Notch Signaling.
Sprinzak et al. (2021)
3 more