› 5mvy

Electron Microscopy
28.4Å resolution

Thin Filament at low calcium concentration

Released:
DOI: 10.2210/pdb5mvy/pdb
PDB entry 5mvy coloured by chain, front view.
PDB entry 5mvy coloured by chain, side view.
PDB entry 5mvy coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Relaxed and active thin filament structures; a new structural basis for the regulatory mechanism.
Paul DM, Squire JM, Morris EP
J Struct Biol 197 365-371 (2017)
PMID: 28161413
Related structures: EMD-3578

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 23-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159322 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin

Ligands and Environments

1 bound ligand:
Ligand ADP 23 x ADP
1 modified residue:
Ligand HIC 23 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 28.4Å
Relevant EMDB volumes: EMD-3578

Quick links

Citations

3 review citations

50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective.
Parry DAD. (2023)
2 more

2 mentions without citation

Relaxed and active thin filament structures; a new structural basis for the regulatory mechanism.
Paul et al. (2017)
1 more