› 5mwf

X-ray diffraction
2.8Å resolution

Human Jagged2 C2-EGF2

Released:
DOI: 10.2210/pdb5mwf/pdb
PDB entry 5mwf coloured by chain, front view.
PDB entry 5mwf coloured by chain, side view.
PDB entry 5mwf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Suckling RJ, Korona B, Whiteman P, Chillakuri C, Holt L, Handford PA, Lea SM
EMBO J 36 2204-2215 (2017)
PMID: 28572448

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Protein jagged-2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 293 amino acids
Theoretical weight: 32.55 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9Y219 (Residues: 27-309; Coverage: 23%)
Gene name: JAG2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand CA 17 x CA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P1
Unit cell:
a: 62.628Å b: 92.929Å c: 97.004Å
α: 71.68° β: 83.16° γ: 82.68°
R-values:
R R work R free
0.22 0.217 0.275
Expression system: Drosophila melanogaster

Quick links

Citations

8 review citations

Notch signaling pathway: architecture, disease, and therapeutics.
Zhou et al. (2022)
7 more

3 mentions without citation

Structural analysis of glycoproteins: building N-linked glycans with Coot.
Emsley et al. (2018)
2 more