› 5n1u

X-ray diffraction
2.98Å resolution

Structure of xEco2 acetyltransferase domain

Released:
DOI: 10.2210/pdb5n1u/pdb
PDB entry 5n1u coloured by chain, front view.
PDB entry 5n1u coloured by chain, side view.
PDB entry 5n1u coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Structural Basis of Eco1-Mediated Cohesin Acetylation.
Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR
Sci Rep 7 44313 (2017)
PMID: 28290497

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108777 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetyltransferase ESCO2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 183 amino acids
Theoretical weight: 20.86 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: A8QZK6 (Residues: 523-702; Coverage: 26%)
Gene name: xeco2
Sequence domains: ESCO1/2 acetyl-transferase

Ligands and Environments

1 bound ligand:
Ligand COA 2 x COA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 58.475Å b: 66.287Å c: 109.763Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.223 0.268
Expression system: Escherichia coli

Quick links

Citations

2 review citations

It's all in the numbers: Cohesin stoichiometry.
Matityahu et al. (2022)
1 more

2 mentions without citation

Structural Basis of Eco1-Mediated Cohesin Acetylation.
Chao et al. (2017)
1 more