› 5nv6

X-ray diffraction
2.93Å resolution

Structure of human transforming growth factor beta-induced protein (TGFBIp).

Released:
DOI: 10.2210/pdb5nv6/pdb
PDB entry 5nv6 coloured by chain, front view.
PDB entry 5nv6 coloured by chain, side view.
PDB entry 5nv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Functional Implications of Human Transforming Growth Factor β-Induced Protein, TGFBIp, in Corneal Dystrophies.
García-Castellanos R, Nielsen NS, Runager K, Thøgersen IB, Lukassen MV, Poulsen ET, Goulas T, Enghild JJ, Gomis-Rüth FX
Structure 25 1740-1750.e2 (2017)
PMID: 28988748

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172330 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transforming growth factor-beta-induced protein ig-h3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 683 amino acids
Theoretical weight: 74.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15582 (Residues: 1-683; Coverage: 100%)
Gene names: BIGH3, TGFBI
Sequence domains: Fasciclin domain

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P61
Unit cell:
a: 114.84Å b: 114.84Å c: 181.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.219 0.263
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Fascinating Fasciclins: A Surprisingly Widespread Family of Proteins that Mediate Interactions between the Cell Exterior and the Cell Surface.
Seifert et al. (2018)
1 more

6 mentions without citation

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities.
Louros et al. (2020)
5 more