› 5oqk

Solution NMR

Solution NMR structure of truncated, human Hv1/VSOP (Voltage-gated proton channel)

Released:
DOI: 10.2210/pdb5oqk/pdb
PDB entry 5oqk coloured by chain, ensemble of 10 models, front view.
PDB entry 5oqk coloured by chain, ensemble of 10 models, side view.
PDB entry 5oqk coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Nuclear Magnetic Resonance Solution Structure and Functional Behavior of the Human Proton Channel.
Bayrhuber M, Maslennikov I, Kwiatkowski W, Sobol A, Wierschem C, Eichmann C, Frey L, Riek R
Biochemistry 58 4017-4027 (2019)
PMID: 31365236

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-gated hydrogen channel 1 Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 17.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96D96 (Residues: 83-226; Coverage: 53%)
Gene names: HVCN1, UNQ578/PRO1140, VSOP
Sequence domains: Ion transport protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 56%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 citation in other articles

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Taylor et al. (2020)
7 more

5 mentions without citation

A Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals.
Delgado-Bermúdez et al. (2022)
4 more