› 5t7q

Solution NMR

TIRAP phosphoinositide-binding motif

Released:
DOI: 10.2210/pdb5t7q/pdb
PDB entry 5t7q coloured by chain, ensemble of 20 models, front view.
PDB entry 5t7q coloured by chain, ensemble of 20 models, side view.
PDB entry 5t7q coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.
Zhao X, Xiong W, Xiao S, Tang TX, Ellena JF, Armstrong GS, Finkielstein CV, Capelluto DG
Sci Rep 7 43043 (2017)
PMID: 28225045

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing adapter protein Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P58753 (Residues: 15-35; Coverage: 10%)
Gene names: MAL, TIRAP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 32%
Refinement method: simulated annealing
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

4 review citations

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies.
Belhaouane et al. (2020)
3 more

2 mentions without citation

Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.
Zhao et al. (2017)
1 more