› 5tbx

X-ray diffraction
1.77Å resolution

hnRNP A18 RNA Recognition Motif

Released:
DOI: 10.2210/pdb5tbx/pdb
PDB entry 5tbx coloured by chain, front view.
PDB entry 5tbx coloured by chain, side view.
PDB entry 5tbx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.
Coburn K, Melville Z, Aligholizadeh E, Roth BM, Varney KM, Carrier F, Pozharski E, Weber DJ
Acta Crystallogr F Struct Biol Commun 73 209-214 (2017)
PMID: 28368279

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171899 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cold-inducible RNA-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 10.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14011 (Residues: 1-91; Coverage: 53%)
Gene names: A18HNRNP, CIRBP, CIRP
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 41.473Å b: 56.149Å c: 72.431Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.218 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Recent progress in the research of cold-inducible RNA-binding protein.
Zhong et al. (2017)
3 more

6 mentions without citation

ATP regulates RNA-driven cold inducible RNA binding protein phase separation.
Zhou et al. (2021)
5 more