› 5thm

X-ray diffraction
2.15Å resolution

Esterase-6 from Drosophila melanogaster

Released:
DOI: 10.2210/pdb5thm/pdb
PDB entry 5thm coloured by chain, front view.
PDB entry 5thm coloured by chain, side view.
PDB entry 5thm coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.
Younus F, Fraser NJ, Coppin CW, Liu JW, Correy GJ, Chertemps T, Pandey G, Maïbèche M, Jackson CJ, Oakeshott JG
Sci Rep 7 46188 (2017)
PMID: 28393888

Function and Biology Details

Reaction catalysed: 
A carboxylic ester + H(2)O = an alcohol + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139954 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Esterase-6 Chain: A
Molecule details ›
Chain: A
Length: 533 amino acids
Theoretical weight: 60.91 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: P08171 (Residues: 8-8, 22-544; Coverage: 98%)
Gene names: CG6917, EST6, Est-6
Sequence domains: Carboxylesterase family

Ligands and Environments

1 bound ligand:
Ligand 7BZ 1 x 7BZ
1 modified residue:
Ligand MLY 32 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 67.713Å b: 80.645Å c: 107.038Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.155 0.21
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Olfactory coding in honeybees.
Paoli et al. (2021)
1 more

3 mentions without citation

An Overview of Antennal Esterases in Lepidoptera.
Godoy et al. (2021)
2 more