› 5tpy

X-ray diffraction
2.8Å resolution

Crystal structure of an exonuclease resistant RNA from Zika virus

Released:
DOI: 10.2210/pdb5tpy/pdb
PDB entry 5tpy coloured by chain, front view.
PDB entry 5tpy coloured by chain, side view.
PDB entry 5tpy coloured by chain, top view.
Source organism: Zika virus
Primary publication:
Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS
Science 354 1148-1152 (2016)
PMID: 27934765

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196977 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (71-MER) Chain: A
Molecule details ›
Chain: A
Length: 71 nucleotides
Theoretical weight: 23.02 KDa
Source organism: Zika virus
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand HEZ 1 x HEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P6422
Unit cell:
a: 111.679Å b: 111.679Å c: 90.826Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.191 0.218
Expression system: Not provided

Quick links

Citations

39 review citations

Biochemistry and Molecular Biology of Flaviviruses.
Barrows et al. (2018)
38 more

23 mentions without citation

Functional RNA structures throughout the Hepatitis C Virus genome.
Adams et al. (2017)
22 more