› 5ts5

X-ray diffraction
2.3Å resolution

Crystal structure of L-amino acid oxidase from Bothrops atrox

Released:
DOI: 10.2210/pdb5ts5/pdb
PDB entry 5ts5 coloured by chain, front view.
PDB entry 5ts5 coloured by chain, side view.
PDB entry 5ts5 coloured by chain, top view.
Source organism: Bothrops atrox
Primary publication:
Crystal structure and molecular dynamics studies of L-amino acid oxidase from Bothrops atrox.
Feliciano PR, Rustiguel JK, Soares RO, Sampaio SV, Cristina Nonato M
Toxicon 128 50-59 (2017)
PMID: 28137621

Function and Biology Details

Reaction catalysed: 
An L-amino acid + H(2)O + O(2) = a 2-oxo carboxylate + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
L-amino-acid oxidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 484 amino acids
Theoretical weight: 55.02 KDa
Source organism: Bothrops atrox
UniProt:
  • Canonical: P0CC17 (Residues: 19-502; Coverage: 99%)
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 4 x FAD
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
3 bound ligands:
Ligand ZN 11 x ZN
Ligand NAG 3 x NAG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P21
Unit cell:
a: 73.64Å b: 123.92Å c: 105.08Å
α: 90° β: 96.03° γ: 90°
R-values:
R R work R free
0.183 0.18 0.23

Quick links

Citations

1 review citation

An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1.
Castellano et al. (2017)
2 other articles

5 mentions without citation

The chemistry of snake venom and its medicinal potential.
Oliveira et al. (2022)
4 more