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HIGH RESOLUTION CRYSTAL STRUCTURE OF A HUMAN TNF-ALPHA MUTANT

X-ray diffraction
2.5Å resolution
PDB entry 5tsw coloured by chain, front view.
PDB entry 5tsw coloured by chain, side view.
PDB entry 5tsw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble tumor necrosis factor complex
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Multimeric state: homo trimer
Accessible surface area: 17958.09 Å2
Buried surface area: 5992.26 Å2
Dissociation area: 2,996.13 Å2
Dissociation energy (ΔGdiss): 20.16 kcal/mol
Dissociation entropy (TΔSdiss): 25.05 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134285
Assembly 2
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Assembly Name: Soluble tumor necrosis factor complex
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Multimeric state: homo trimer
Accessible surface area: 18223.82 Å2
Buried surface area: 5940.34 Å2
Dissociation area: 2,970.17 Å2
Dissociation energy (ΔGdiss): 22.06 kcal/mol
Dissociation entropy (TΔSdiss): 25.02 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134285

Macromolecules

Tumor necrosis factor, soluble form
Chains: A, B, C, D, E, F
Length: 150 amino acids
Theoretical weight: 16.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01375 (Residues: 84-233; Coverage: 64%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls
SCOP: TNF-like
Tumor necrosis factor, soluble form in PDB entry 5tsw, assembly 1, front view.
Tumor necrosis factor, soluble form in PDB entry 5tsw, assembly 1, side view.
Tumor necrosis factor, soluble form in PDB entry 5tsw, assembly 1, top view.
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