› 5tub

X-ray diffraction
2.85Å resolution

Crystal Structure of the Shark TBC1D15 GAP Domain

Released:
DOI: 10.2210/pdb5tub/pdb
PDB entry 5tub coloured by chain, front view.
PDB entry 5tub coloured by chain, side view.
PDB entry 5tub coloured by chain, top view.
Source organism: Squalomorphii
Primary publication:
Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Chen YN, Gu X, Zhou XE, Wang W, Cheng D, Ge Y, Ye F, Xu HE, Lv Z
Protein Sci 26 834-846 (2017)
PMID: 28168758

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rab-GAP TBC domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 348 amino acids
Theoretical weight: 41.5 KDa
Source organism: Squalomorphii
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A1U7Q1Z6 (Residues: 1-348; Coverage: 100%)
Sequence domains: Rab-GTPase-TBC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2
Unit cell:
a: 224.79Å b: 149.74Å c: 95.03Å
α: 90° β: 108.93° γ: 90°
R-values:
R R work R free
0.217 0.215 0.248
Expression system: Escherichia coli

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Citations

1 review citation

The multi-faced role of FUNDC1 in mitochondrial events and human diseases.
Tan et al. (2022)
3 other articles

3 mentions without citation

Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Chen et al. (2017)
2 more