› 5tvb

X-ray diffraction
2.75Å resolution

Structure of the TPR oligomerization domain

Released:
DOI: 10.2210/pdb5tvb/pdb
PDB entry 5tvb coloured by chain, front view.
PDB entry 5tvb coloured by chain, side view.
PDB entry 5tvb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Pal K, Bandyopadhyay A, Zhou XE, Xu Q, Marciano DP, Brunzelle JS, Yerrum S, Griffin PR, Vande Woude G, Melcher K, Xu HE
Structure 25 867-877.e3 (2017)
PMID: 28528776

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein TPR Chains: A, B
Molecule details ›
Chains: A, B
Length: 141 amino acids
Theoretical weight: 16.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12270 (Residues: 2-142; Coverage: 6%)
Gene name: TPR

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 74.355Å b: 50.669Å c: 94.656Å
α: 90° β: 108.01° γ: 90°
R-values:
R R work R free
0.247 0.242 0.303
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting.
Farrell et al. (2018)
2 more

1 mention without citation

Protein Tetratricopeptide Repeat and the Companion Non-tetratricopeptide Repeat Helices: Bioinformatic Analysis of Interhelical Interactions.
Barik S. (2019)