› 5txd

X-ray diffraction
1.45Å resolution

Structure of amyloid-beta derived peptide - NKGAIF

Released:
DOI: 10.2210/pdb5txd/pdb
PDB entry 5txd coloured by chain, front view.
PDB entry 5txd coloured by chain, side view.
PDB entry 5txd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Distal amyloid β-protein fragments template amyloid assembly.
Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT
Protein Sci 27 1181-1190 (2018)
PMID: 29349888

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chain: Z
Molecule details ›
Chain: Z
Length: 6 amino acids
Theoretical weight: 650 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 698-703; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 29.402Å b: 4.827Å c: 26.612Å
α: 90° β: 102.04° γ: 90°
R-values:
R R work R free
0.176 0.174 0.191
Expression system: Not provided

Quick links

Citations

1 review citation

Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta.
Wagner et al. (2022)
2 other articles

1 mention without citation

Distal amyloid β-protein fragments template amyloid assembly.
Do et al. (2018)