› 5tzy

X-ray diffraction
3.22Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Free fatty acid receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 491 amino acids
Theoretical weight: 53.18 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14842 (Residues: 1-211, 214-300; Coverage: 99%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: E, FFAR1, GPR40
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand OLC 1 x OLC
Ligand MK6 1 x MK6
Ligand 7OS 1 x 7OS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 53.88Å b: 63.95Å c: 90.96Å
α: 90° β: 90.52° γ: 90°
R-values:
R R work R free
0.27 0.269 0.287
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

Structural insights into G-protein-coupled receptor allostery.
Thal et al. (2018)
11 more

39 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
38 more