› 5uhm

X-ray diffraction
1.9Å resolution

Apo-Structure of Mature Growth Differentiation Factor 11

Released:
DOI: 10.2210/pdb5uhm/pdb
PDB entry 5uhm coloured by chain, front view.
PDB entry 5uhm coloured by chain, side view.
PDB entry 5uhm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for potency differences between GDF8 and GDF11.
Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB
BMC Biol 15 19 (2017)
PMID: 28257634

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth/differentiation factor 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95390 (Residues: 299-407; Coverage: 29%)
Gene names: BMP11, GDF11
Sequence domains: Transforming growth factor beta like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P3221
Unit cell:
a: 65.16Å b: 65.16Å c: 101.942Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.258
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis.
Walton et al. (2017)
13 more

1 mention without citation

Structural basis for potency differences between GDF8 and GDF11.
Walker et al. (2017)