5up2

Electron Microscopy
6Å resolution

Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5

Released:
Source organisms:
Related structures: EMD-8581

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-103596 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 836 amino acids
Theoretical weight: 94.06 KDa
Source organism: Xenopus laevis
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1L8F5J9 (Residues: 1-836; Coverage: 92%)
Gene name: grin1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2A Chain: B
Molecule details ›
Chain: B
Length: 831 amino acids
Theoretical weight: 93.54 KDa
Source organism: Xenopus laevis
Expression system: Homo sapiens
UniProt:
  • Canonical: B7ZSK1 (Residues: 1-834; Coverage: 57%)
Gene name: grin2a
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chain: D
Molecule details ›
Chain: D
Length: 837 amino acids
Theoretical weight: 94.55 KDa
Source organism: Xenopus laevis
Expression system: Homo sapiens
UniProt:
  • Canonical: A7XY94 (Residues: 1-840; Coverage: 57%)
Gene name: grin2b
Sequence domains:
GluN2B-specific Fab, termed 11D1 Chains: F, G
Molecule details ›
Chains: F, G
Length: 216 amino acids
Theoretical weight: 18.4 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-8581
Expression system: Homo sapiens