Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-150315 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cyclin-dependent kinase 2
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 34.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 301 amino acids
Theoretical weight: 34.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P24941 (Residues: 1-298; Coverage: 100%)
Sequence domains: Protein kinase domain
Structure domains:
Speedy protein A
Molecule details ›
Chain: B
Length: 160 amino acids
Theoretical weight: 19.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cell cycle regulatory protein
Length: 160 amino acids
Theoretical weight: 19.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q5MJ70 (Residues: 61-213; Coverage: 49%)
Sequence domains: Cell cycle regulatory protein
Cyclin-dependent kinase inhibitor 1B
Molecule details ›
Chain: C
Length: 201 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cyclin-dependent kinase inhibitor
Length: 201 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P46527 (Residues: 1-198; Coverage: 100%)
Sequence domains: Cyclin-dependent kinase inhibitor
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 23-ID-D
Spacegroup:
P3121
Expression system: Escherichia coli
