› 5uqf

X-ray diffraction
2.73Å resolution

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with IMP and the inhibitor P225

Released:
DOI: 10.2210/pdb5uqf/pdb
PDB entry 5uqf coloured by chain, front view.
PDB entry 5uqf coloured by chain, side view.
PDB entry 5uqf coloured by chain, top view.
Source organism: Campylobacter jejuni subsp. jejuni
Entry authors: Kim Y, Maltseva N, Makowska-Grzyska M, Gu M, Gollapalli D, Hedstrom L, Anderson WF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-166175 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 406 amino acids
Theoretical weight: 43.52 KDa
Source organism: Campylobacter jejuni subsp. jejuni
Expression system: Escherichia coli BL21(DE3)
Structure domains: Aldolase class I

Ligands and Environments

7 bound ligands:
Ligand IMP 3 x IMP
Ligand 8KY 3 x 8KY
Ligand K 3 x K
Ligand SO4 10 x SO4
Ligand EDO 6 x EDO
Ligand GOL 2 x GOL
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I422
Unit cell:
a: 118.526Å b: 118.526Å c: 451.298Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.228
Expression system: Escherichia coli BL21(DE3)

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