› 5uqg

X-ray diffraction
2.03Å resolution

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p200

Released:
DOI: 10.2210/pdb5uqg/pdb
PDB entry 5uqg coloured by chain, front view.
PDB entry 5uqg coloured by chain, side view.
PDB entry 5uqg coloured by chain, top view.
Source organism: Campylobacter jejuni subsp. jejuni
Entry authors: Kim Y, Maltseva N, Makowska-Grzyska M, Gu M, Gollapalli D, Hedstrom L, Anderson WF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 406 amino acids
Theoretical weight: 43.52 KDa
Source organism: Campylobacter jejuni subsp. jejuni
Expression system: Escherichia coli BL21(DE3)
Structure domains: Aldolase class I

Ligands and Environments

4 bound ligands:
Ligand IMP 8 x IMP
Ligand 8L4 8 x 8L4
Ligand EDO 2 x EDO
Ligand K 8 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 95.887Å b: 137.963Å c: 116.548Å
α: 90° β: 95.99° γ: 90°
R-values:
R R work R free
0.168 0.166 0.203
Expression system: Escherichia coli BL21(DE3)

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