› 5uzq

X-ray diffraction
2.16Å resolution

Crystal structure of citrate synthase from homo sapiens

Released:
DOI: 10.2210/pdb5uzq/pdb
PDB entry 5uzq coloured by chain, front view.
PDB entry 5uzq coloured by chain, side view.
PDB entry 5uzq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
Schlachter CR, Klapper V, Radford T, Chruszcz M
Biol Chem 400 1567-1581 (2019)
PMID: 31141475

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Citrate synthase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 462 amino acids
Theoretical weight: 51.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75390 (Residues: 28-466; Coverage: 94%)
Gene name: CS
Sequence domains: Citrate synthase, C-terminal domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CME 2 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P41212
Unit cell:
a: 76.76Å b: 76.76Å c: 198.764Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.232
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pathogenicity and virulence of Aspergillus fumigatus.
Earle et al. (2023)
1 more

1 mention without citation

Dynamic Interplay between Copper Toxicity and Mitochondrial Dysfunction in Alzheimer's Disease.
Tassone et al. (2021)