Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Acriflavin resistance protein
- Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains
- RND efflux pump, membrane fusion protein, barrel-sandwich domain
- RND efflux pump, membrane fusion protein
- Cation efflux system protein CusB, domain 1
- Outer membrane efflux protein
- Multidrug resistance protein MdtF-like
- Type I secretion outer membrane protein, TolC
Structure analysis Details
Assembly composition:
hetero dodecamer (preferred)
Assembly name:
AcrAB-TolC multidrug efflux transport complex (preferred)
PDBe Complex ID:
PDB-CPX-136395 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Outer membrane protein TolC
Molecule details ›
Chains: A, B, C
Length: 442 amino acids
Theoretical weight: 48.67 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
Sequence domains: Outer membrane efflux protein
Length: 442 amino acids
Theoretical weight: 48.67 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
- Canonical:
P02930 (Residues: 23-464; Coverage: 94%)
Sequence domains: Outer membrane efflux protein
Multidrug efflux pump subunit AcrA
Molecule details ›
Multidrug efflux pump subunit AcrB
Molecule details ›
Chains: J, K, L
Length: 1049 amino acids
Theoretical weight: 113.68 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
Sequence domains: AcrB/AcrD/AcrF family
Length: 1049 amino acids
Theoretical weight: 113.68 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
- Canonical: P31224 (Residues: 1-1049; Coverage: 100%)
Sequence domains: AcrB/AcrD/AcrF family
