› 5vb9

X-ray diffraction
1.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166203 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-17A Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.75 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q16552 (Residues: 38-155; Coverage: 89%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines
Peptide inhibitor Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.85 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 36.771Å b: 55.122Å c: 143.953Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.211
Expression systems:
  • Baculovirus expression vector pFastBac1-HM
  • Not provided

Quick links

Citations

2 review citations

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Proteinā»Protein Interactions.
Robertson et al. (2018)
1 more

2 mentions without citation

Docking Flexible Cyclic Peptides with AutoDock CrankPep.
Zhang et al. (2019)
1 more