› 5vhy

Electron Microscopy
4.6Å resolution

GluA2-2xGSG1L bound to ZK

Released:
DOI: 10.2210/pdb5vhy/pdb
PDB entry 5vhy coloured by chain, front view.
PDB entry 5vhy coloured by chain, side view.
PDB entry 5vhy coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Neuron 94 569-580.e5 (2017)
PMID: 28472657
Related structures: EMD-8687

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112605 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Germ cell-specific gene 1-like protein; Glutamate receptor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 1057 amino acids
Theoretical weight: 117.47 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: D3ZK93 (Residues: 2-238; Coverage: 74%)
Gene names: GluA2, Glur2, Gria2, Gsg1l
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ZK1 4 x ZK1
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-8687
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
10 more

4 mentions without citation

Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes.
Twomey et al. (2019)
3 more