› 5vhz

Electron Microscopy
8.4Å resolution

GluA2-2xGSG1L bound to L-Quisqualate

Released:
DOI: 10.2210/pdb5vhz/pdb
PDB entry 5vhz coloured by chain, front view.
PDB entry 5vhz coloured by chain, side view.
PDB entry 5vhz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Neuron 94 569-580.e5 (2017)
PMID: 28472657
Related structures: EMD-8688

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112605 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Germ cell-specific gene 1-like protein; Glutamate receptor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 1057 amino acids
Theoretical weight: 117.47 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: D3ZK93 (Residues: 2-238; Coverage: 74%)
Gene names: GluA2, Glur2, Gria2, Gsg1l
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand QUS 4 x QUS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.4Å
Relevant EMDB volumes: EMD-8688
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
10 more

13 mentions without citation

Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects.
Golubeva et al. (2022)
12 more