› 5vic

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-143701 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 234 amino acids
Theoretical weight: 24.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-117, 118-123, 124-242; Coverage: 50%)
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin kappa light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX7 (Residues: 1-214; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins
Envelope protein Chain: E
Molecule details ›
Chain: E
Length: 99 amino acids
Theoretical weight: 10.79 KDa
Source organism: Dengue virus 1 Nauru/West Pac/1974
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8BE39 (Residues: 298-396; Coverage: 20%)
Gene name: E
Sequence domains: Flavivirus glycoprotein, immunoglobulin-like domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P43212
Unit cell:
a: 74.225Å b: 74.225Å c: 190.758Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.286
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)

Quick links

Citations

47 review citations

The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design.
Rey et al. (2018)
46 more

7 mentions without citation

The A-Z of Zika drug discovery.
Mottin et al. (2018)
6 more