› 5vvm

X-ray diffraction
3.54Å resolution

Crystal structure of human CDH23 EC21-23

Released:
DOI: 10.2210/pdb5vvm/pdb
PDB entry 5vvm coloured by chain, front view.
PDB entry 5vvm coloured by chain, side view.
PDB entry 5vvm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M
Structure 26 1210-1225.e4 (2018)
PMID: 30033219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chains: A, B
Molecule details ›
Chains: A, B
Length: 346 amino acids
Theoretical weight: 37.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H251 (Residues: 2169-2505; Coverage: 10%)
Gene names: CDH23, KIAA1774, KIAA1812, UNQ1894/PRO4340
Sequence domains: Cadherin domain

Ligands and Environments

1 bound ligand:
Ligand CA 12 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-003
Spacegroup: C2
Unit cell:
a: 116.714Å b: 166.806Å c: 47.93Å
α: 90° β: 102.53° γ: 90°
R-values:
R R work R free
0.305 0.303 0.346
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.
Fettiplace et al. (2019)
1 more

2 mentions without citation

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh et al. (2018)
1 more