› 5w1j

X-ray diffraction
2.7Å resolution

Echinococcus granulosus thioredoxin glutathione reductas (egTGR)

Released:
DOI: 10.2210/pdb5w1j/pdb
PDB entry 5w1j coloured by chain, front view.
PDB entry 5w1j coloured by chain, side view.
PDB entry 5w1j coloured by chain, top view.
Source organism: Echinococcus granulosus
Primary publication:
The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).
Salinas G, Gao W, Wang Y, Bonilla M, Yu L, Novikov A, Virginio VG, Ferreira HB, Vieites M, Gladyshev VN, Gambino D, Dai S
Antioxid Redox Signal 27 1491-1504 (2017)
PMID: 28463568

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183117 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-disulfide reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 584 amino acids
Theoretical weight: 64.34 KDa
Source organism: Echinococcus granulosus
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q869D7 (Residues: 34-617; Coverage: 94%)
Gene name: TGR
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FAD 2 x FAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 108.74Å b: 108.74Å c: 257.064Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.26
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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Citations

6 citation in other articles

Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections.
Feng et al. (2020)
5 more

2 mentions without citation

Proton currents constrain structural models of voltage sensor activation.
Randolph et al. (2016)
1 more