› 5w2l

X-ray diffraction
1.86Å resolution

Structure of a central domain of human Ctc1

Released:
DOI: 10.2210/pdb5w2l/pdb
PDB entry 5w2l coloured by chain, front view.
PDB entry 5w2l coloured by chain, side view.
PDB entry 5w2l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.
Shastrula PK, Rice CT, Wang Z, Lieberman PM, Skordalakes E
Nucleic Acids Res 46 972-984 (2018)
PMID: 29228254

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CST complex subunit CTC1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 18.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2NKJ3 (Residues: 716-880; Coverage: 14%)
Gene names: C17orf68, CTC1

Ligands and Environments

1 bound ligand:
Ligand HG 6 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 47.537Å b: 50.776Å c: 144.538Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.249
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Lim et al. (2021)
4 more

7 mentions without citation

Structural biology of telomeres and telomerase.
Smith et al. (2020)
6 more