› 5w3r

X-ray diffraction
1.39Å resolution

SH2B1 SH2 Domain

Released:
DOI: 10.2210/pdb5w3r/pdb
PDB entry 5w3r coloured by chain, front view.
PDB entry 5w3r coloured by chain, side view.
PDB entry 5w3r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Diversity in peptide recognition by the SH2 domain of SH2B1.
McKercher MA, Guan X, Tan Z, Wuttke DS
Proteins 86 164-176 (2018)
PMID: 29127727

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192554 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH2B adapter protein 1 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NRF2 (Residues: 519-628; Coverage: 15%)
Gene names: KIAA1299, SH2B, SH2B1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand IPH 3 x IPH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 29.01Å b: 52.75Å c: 60.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.144 0.168
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro.
Lloyd et al. (2021)