› 5wem

Electron Microscopy
6.1Å resolution

GluA2 bound to GSG1L in digitonin, state 1

Released:
DOI: 10.2210/pdb5wem/pdb
PDB entry 5wem coloured by chain, front view.
PDB entry 5wem coloured by chain, side view.
PDB entry 5wem coloured by chain, top view.
Source organisms:
Primary publication:
Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Nature 549 60-65 (2017)
PMID: 28737760
Related structures: EMD-8821

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112594 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Germ cell-specific gene 1-like protein; Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1057 amino acids
Theoretical weight: 117.47 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: D3Z7H4 (Residues: 2-238; Coverage: 74%)
Gene names: GluA2, Glur2, Gria2, Gsg1l
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.1Å
Relevant EMDB volumes: EMD-8821
Expression system: Homo sapiens

Quick links

Citations

31 review citations

Progress in nicotinic receptor structural biology.
Gharpure et al. (2020)
30 more

5 mentions without citation

Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects.
Golubeva et al. (2022)
4 more